To prevent your pc from virus threat its better that you disable auto run drives. Because many virus comes when you attach your pen drive or cd-rom and its activated.
So its better to Disable Auto run of your drives.
To do it..
Go to Start-->Run-->fire command gpedit.msc
It will show you the General Policy window. In left pane there is Tree view There is two nodes
1)Computer Configuration
2)User Configuration
In 1) Computer Configuration there are Three nodes
i)Software Settings
ii)Windows Settings
iii)Administrative Templates
In Administrative Templates just click on the System node and on the right pane you will find many options.
Turn off AutoPlay
In that select Properties and set it to enabled to turn off your auto play of drives.